The Covid epidemic has been disastrous to the world. There was a 70-year-old man who came to the hospital due to covid pneumonia. Since there hasn’t been a good research treatment for covid, the trial and error scenarios have damage patients—the 70-year-old man who was placed on multiple antibiotics. One of the antibiotics was a new drug call Remdesivir. According to Beigel et al.(2020), those who received remdesivir had a median recovery time of 10 days (95% confidence interval as compared with 15 days (95% CI, 13 to 18) among those who received placebo (rate ratio for recovery.
Most of the time, clinical new emergency drugs have limited research on adverse effects, especially on the elderly populations. Several clinical trials using Remdesivir as a treatment for infected COVID-19 patients are undergoing around the world. Most elderly patients with covid have comorbidities such as heart, liver, and kidney diseases. In old age, renal function often declines. Older adults have smaller kidneys and fewer nephrons. The loss of nephrons results in decreased blood filtration. Additionally, vessel changes such as atherosclerosis reduce renal blood flow. As a result, renal excretion of drugs is decreased. My patient had an acute kidney injury. He was getting intravenous fluid and Remdesivir together. Later on, he developed fluid overload and was placed on Lasix. The Lasix mixed with remdesivir decreased his kidney functions and later on led to congestive heart failure.
The ability of older adults to metabolize drugs is commonly decreased. Drug dosages may need to be reduced to prevent drug toxicity. Ways on how to avoid this situation will be accounting for the pharmacokinetic and pharmacodynamic changes that occur with aging, initiating therapy with low doses and titrating upward gradually (“start low and go slow”) and monitoring for drug-drug interactions and iatrogenic illness(Rosentha &Burchum, 2021). Another intervention is to consult a specialist earlier—all hands on deck. Studies have found that multidisciplinary care for elderly patients with kidney disease is associated with improved survival
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